Statistical Issues in Toxicokinetic Modeling: A Bayesian Perspective
نویسندگان
چکیده
منابع مشابه
Statistical issues in toxicokinetic modeling: a bayesian perspective.
Determining the relationship between an exposure and the resulting target tissue dose is a critical issue encountered in quantitative risk assessment (QRA). Classical or physiologically based toxicokinetic (PBTK) models can be useful in performing that task. Interest in using these models to improve extrapolations between species, routes, and exposure levels in QRA has therefore grown considera...
متن کاملStatistical Information: A Bayesian Perspective
We explore the meaning of information about quantities of interest. Our approach is divided in two scenarios: the analysis of observations and the planning of an experiment. First, we review the Sufficiency, Conditionality and Likelihood principles and how they relate to trivial experiments. Next, we review Blackwell Sufficiency and show that sampling without replacement is Blackwell Sufficient...
متن کاملon some bayesian statistical models in actuarial science with emphasis on claim count
چکیده ندارد.
15 صفحه اول22. Bayesian Ying Yang Learning (I): A Unified Perspective for Statistical Modeling
Major dependence structure mining tasks are overviewed from a general statistical learning perspective. Bayesian Ying Yang (BYY) harmony learning has been introduced as a unified framework for mining these dependence structures, with new mechanisms for model selection and regularization on a finite size of samples. Main results are summarized and bibliographic remarks are made. Two typical appr...
متن کاملPhysiologically Based Toxicokinetic (PBTK) Modeling in Ecotoxicology
Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals in biota. PBTK models are increasingly being used as an effective tool for designing toxicology experiments and for conducting extrapolations essential for risk assessme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2000
ISSN: 0091-6765
DOI: 10.1289/ehp.00108s5883